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Association between polymorphisms of NOS1, NOS2 and NOS3 genes and suicide behavior: a systematic review and

Thelma Beatriz González-Castro, Alma Delia Genis-Mendoza, Carlos Alfonso Tovilla-Zárate1

  • 1División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Ranchería Sur, Cuarta Sección, C.P, 86650, Comalcalco, Tabasco, Mexico. alfonso_tovillaz@yahoo.com.mx.

Metabolic Brain Disease
|March 23, 2019
PubMed

Insights

Genetic variations in nitric oxide synthase 1 (NOS1) may increase suicide attempt risk. Specifically, the NOS1 rs2682826 variant is linked to higher risk, though further research is needed to confirm this association.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Nitric oxide synthase (NOS) enzymes are crucial for nitric oxide production.
  • NOS enzymes have been previously linked to suicidal behavior.
  • The specific genetic associations between NOS genes and suicide behavior remain unclear.

Purpose of the Study:

  • To systematically review and meta-analyze existing studies on the association between Nitric Oxide Synthase (NOS) genes and suicide behavior.
  • To investigate the role of NOS1, NOS2, and NOS3 gene variants in suicide risk.

Main Methods:

  • Systematic literature search of PubMed, Scopus, and Web of Science databases up to February 2019.
  • Meta-analysis using allelic, dominant, recessive, homozygous, and heterozygous models.
  • Inclusion of studies investigating "NOS" genes and "suicide" behavior.

Main Results:

  • The rs2682826 variant in the Nitric Oxide Synthase 1 (NOS1) gene was associated with an increased risk of suicide attempt.
  • This association was observed in allelic (OR: 1.34), recessive (OR: 1.45), and heterozygous (OR: 1.41) models.
  • No definitive conclusions were drawn for NOS2 and NOS3 genes.

Conclusions:

  • The NOS1 rs2682826 variant may be a risk factor for suicide attempts.
  • These findings are preliminary and require further investigation.
  • Additional research is necessary to fully elucidate the relationship between NOS genes and suicide behavior.
Keywords:
Biochemical markersBiological psychiatryNOS geneNeuropsychiatrySuicide

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