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Updated: Jan 27, 2026

Rapid Repetition Rate Fluctuation Measurement of Soliton Crystals in a Microresonator
Published on: December 15, 2021
Resting-state amplitude of low-frequency fluctuation is associated with suicidal ideation
Martin J Lan1,2, Mina M Rizk1,2,3, Spiro P Pantazatos1,2
1Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York.
Background:
Identifying brain activity patterns that are associated with suicidal ideation (SI) may help to elucidate its pathogenesis and etiology. Suicide poses a significant public health problem, and SI is a risk factor for suicidal behavior.
Methods:
Forty-one unmedicated adult participants in a major depressive episode (MDE), 26 with SI on the Beck Scale for Suicidal Ideation and 15 without SI, underwent resting-state functional magnetic resonance imaging scanning. Twenty-one healthy volunteers (HVs) were scanned for secondary analyses. Whole brain analysis of both amplitude of low-frequency fluctuations (ALFFs) and fractional ALFF was performed in MDE subjects to identify regions where activity was associated with SI.
Results:
Subjects with SI had greater ALFF than those without SI in two clusters: one in the right hippocampus and one in the thalamus and caudate, bilaterally. Multi-voxel pattern analysis distinguished between those with and without SI. Post hoc analysis of the mean ALFF in the hippocampus cluster found it to be associated with a delayed recall on the Buschke memory task. Mean ALFF from the significant clusters was not associated with depression severity and did not differ between MDE and HV groups.
Discussion:
These results indicate that SI is associated with altered resting-state brain activity. The pattern of elevated activity in the hippocampus may be related to how memories are processed.
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