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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Updated: Jan 27, 2026

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
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Stem cell therapies for wound healing.

Nina Kosaric1, Harriet Kiwanuka1, Geoffrey C Gurtner1

  • 1a Hagey Laboratory for Pediatric Regenerative Medicine; Division of Plastic and Reconstructive Surgery, Department of Surgery , Stanford University School of Medicine , Stanford , CA , USA.

Expert Opinion on Biological Therapy
|March 23, 2019
PubMed
Summary

Stem cell therapy, especially using mesenchymal stromal cells, shows promise for accelerating wound healing. Further research is needed to optimize this approach for chronic wound management in aging and diabetic patients.

Keywords:
Adipose stem cellscellular heterogeneitychronic woundsgenetic engineeringmesenchymal stromal cellsstem cellswound healing

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Area of Science:

  • Regenerative Medicine
  • Wound Healing Biology
  • Cell-Based Therapies

Background:

  • Aberrant wound healing presents a significant healthcare challenge, particularly for aging and diabetic populations.
  • Current treatments for chronic wounds are often only moderately effective.
  • Stem cell therapy offers a promising avenue for tissue regeneration and improved wound closure.

Purpose of the Study:

  • To review current wound healing management strategies.
  • To provide an overview of stem cell therapy for wound healing.
  • To discuss considerations for optimizing stem cell therapy.

Main Methods:

  • Literature review of wound healing and stem cell therapy.
  • Analysis of factors influencing stem cell efficacy in wound healing.
  • Discussion of future research directions.

Main Results:

  • Mesenchymal stromal cells demonstrate potential in accelerating wound healing.
  • Stem cells modulate immune responses and promote angiogenesis.
  • Optimization requires further research into mechanisms and standardization.

Conclusions:

  • Stem cell therapy, particularly with mesenchymal stromal cells, holds significant potential for improving wound healing rates and quality.
  • Further basic and clinical research is essential to refine therapeutic mechanisms and standardize clinical trial protocols.
  • Optimizing stem cell therapy involves careful consideration of cell type, source, delivery, and genetic modification.