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Neuropathic Pain Screening: Construct Validity in Patients With Sickle Cell Disease
Keesha Powell-Roach1, Yingwei Yao1,2, Miriam O Ezenwa1
1University of Florida, Gainesville, FL, USA.
Western Journal of Nursing Research
|March 23, 2019
Summary
Neuropathic pain is common in sickle cell disease (SCD). The PAINReportIt neuropathic pain subscale (PR-NNP) shows construct validity and can help screen for neuropathic pain in SCD patients.
Area of Science:
- Pain Medicine
- Neurology
- Hematology
Background:
- Sickle cell disease (SCD) patients often experience chronic pain.
- Pain management in SCD typically targets nociceptive pain, but neuropathic pain may also be present.
- The PAINReportIt neuropathic pain subscale (PR-NNP) is a potential tool for assessing neuropathic pain in SCD but requires validation.
Purpose of the Study:
- To determine the construct validity of the PR-NNP in adults with SCD and chronic pain.
- To assess the correlation between PR-NNP and established neuropathic pain measures.
Main Methods:
- 186 adult SCD patients with chronic pain completed the PAINReportIt, Neuropathic Pain Symptom Inventory (NPSI), and Leeds Assessment for Neuropathic Symptoms and Signs (S-LANSS).
- Statistical analyses included correlation and regression to evaluate PR-NNP validity.
Main Results:
- PR-NNP demonstrated moderate correlations with NPSI (r = 0.33, p < .001) and S-LANSS (r = 0.40, p < .001).
- PR-NNP and pain intensity significantly predicted NPSI and S-LANSS scores, whereas a nociceptive pain subscale did not.
Conclusions:
- The findings support the construct validity of the PR-NNP.
- PR-NNP may serve as a valuable screening tool for identifying neuropathic pain in individuals with sickle cell disease.
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