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Mechanistic target of rapamycin signaling in mouse models of accelerated aging

Jin Young Lee1, Brian K Kennedy1,2,3,4, Chen-Yu Liao1

  • 1Buck Institute for Research on Aging, Novato, California.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|March 23, 2019
PubMed

Insights

Targeting mechanistic target of rapamycin (mTOR) signaling shows varied effects on aging in mouse models. This review examines how modulating mTOR impacts aging phenotypes and related disorders.

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Gerontology

Background:

  • Mechanistic target of rapamycin (mTOR) is a key nutrient-sensing kinase regulating vital cellular functions like growth, metabolism, and autophagy.
  • Dysregulated mTOR signaling is linked to human diseases, particularly age-related conditions and accelerated aging in mouse models.

Purpose of the Study:

  • To review the impact of mTOR signaling modulation on aging phenotypes across diverse accelerated aging mouse models.
  • To discuss the implications of these findings for understanding aging and age-related disorders.

Main Methods:

  • Literature review of studies investigating mTOR signaling interventions in mouse models of accelerated aging.
  • Analysis of reported effects on aging-associated phenotypes.

Main Results:

  • While some studies show beneficial effects of mTOR targeting on longevity and aging phenotypes in mice.
  • Not all accelerated aging mouse models exhibit positive responses to mTOR pathway modulation.

Conclusions:

  • The effect of targeting mTOR signaling on aging is complex and model-dependent.
  • Further research is needed to clarify mTOR's role in aging and its therapeutic potential for age-related diseases.
Keywords:
Age-associated diseaseDietary restrictionMiceRapamycinmTORC1

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