Cobalt-Catalyzed Three-Component Difluoroalkylation-Peroxidation of Alkenes
Yuanjin Chen1, Liangkui Li1, Yangyang Ma1
1Department of Chemistry , Renmin University of China , Beijing 100872 , China.
Abstract:
The Co(acac)2-catalyzed three-component difluoroalkylation-peroxidation of alkenes with difluorohaloactates and hydroperoxides has been developed. The protocol provides an efficient and selective access to various β-peroxyl difluoroalkyl derivatives, which can be transformed into α-amino acid and pyrimidine derivatives by the reactions with amines and amidines. The mild reaction conditions, broad substrate scopes, gram-scale synthesis, and synthetic applications exemplified the utility and practicability of this method. In addition, this methodology can be extended to other halide compounds to give the alkylation-peroxidation products.
Related Concept Videos
Acid-Catalyzed Hydration of Alkenes
Acid-Catalyzed Dehydration of Alcohols to Alkenes
Nomenclature of Alkenes
As per the IUPAC rules, the longest carbon chain containing the maximum number of double bonds is identified as the parent chain and is numbered such that the doubly bonded carbon atoms receive the lowest possible numbers. The location of the double bond is indicated by the number of its first carbon atom. In branched...
Isomerism in Alkenes
An isomer is called cis-2-butene when the methyl groups are on the same side of the double bond, and the other stereoisomer, in which methyl groups are on the opposite side of the double bond, is called trans-2-butene. The cis and trans stereoisomers are not...
Halogenation of Alkenes
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
Acid-Catalyzed Ring-Opening of Epoxides


