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Benefits of hepatitis C cure with antivirals: why test and treat?

Gema Lledó1, Laura Benítez-Gutiérrez1, Ana Arias1

  • 1Internal Medicine Department, Hospital Puerta de Hierro-Majadahonda, Madrid, Spain.

Future Microbiology
|March 23, 2019
PubMed

Insights

Direct-acting antivirals offer a high cure rate for chronic hepatitis C virus (HCV) infection, leading to liver improvements and reduced cancer risk. Eradicating HCV also yields significant extrahepatic benefits, including better brain function and heart health.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Chronic hepatitis C virus (HCV) infection remains a significant global health concern.
  • Direct-acting antivirals (DAAs) represent a breakthrough in HCV treatment.
  • DAAs offer high cure rates, even in patients with advanced liver disease.

Purpose of the Study:

  • To review the efficacy and benefits of direct-acting antivirals for HCV.
  • To highlight the impact of HCV eradication on both hepatic and extrahepatic conditions.
  • To discuss the role of DAAs in global HCV transmission control.

Main Methods:

  • Literature review of studies on direct-acting antiviral therapy for HCV.
  • Analysis of clinical outcomes, including viral eradication, liver fibrosis, and hepatocellular carcinoma risk.
  • Evaluation of extrahepatic manifestations and public health implications.

Main Results:

  • DAAs achieve high sustained virologic response rates, leading to HCV elimination.
  • HCV cure is associated with regression of liver fibrosis and reduced risk of hepatocellular carcinoma.
  • Sustained HCV eradication demonstrates extrahepatic benefits, such as improved neurocognitive function and cardiovascular health.

Conclusions:

  • Direct-acting antivirals are highly effective for curing chronic HCV infection.
  • HCV eradication provides significant hepatic and extrahepatic advantages.
  • DAAs are crucial in reducing global HCV transmission in the absence of a vaccine.

Keywords:
DAAchronic hepatitis Cextrahepatic manifestationsliver cancerliver fibrosis

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