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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Pleura of the Lungs01:13

Pleura of the Lungs

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Updated: Jan 27, 2026

Tracheotomy: A Method for Transplantation of Stem Cells to the Lung
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Tracheotomy: A Method for Transplantation of Stem Cells to the Lung

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Endogenous lung stem cells for lung regeneration.

Jonathan L McQualter1

  • 1a School of Health and Biomedical Sciences , RMIT University , Melbourne , Australia.

Expert Opinion on Biological Therapy
|March 23, 2019
PubMed
Summary

Maintaining lung health relies on stem cells. Evolving research reveals complex lung stem and progenitor cell roles in tissue maintenance and regeneration, crucial for developing new lung disease therapies.

Keywords:
AT1 cellsAT2 cellsLung regenerationbasal cellslineage hierarchysecretory cellsstem cells

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Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells
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Area of Science:

  • Pulmonary Medicine
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • The adult lung requires resident stem cells for lifelong maintenance and repair.
  • Previously considered quiescent, lung stem and progenitor cells exhibit complex differentiation landscapes.
  • Understanding these cells is vital for lung homeostasis and disease treatment.

Purpose of the Study:

  • To review the hierarchical organization of lung epithelial stem cells.
  • To explore their roles in tissue homeostasis and regeneration after injury.
  • To discuss how new technologies challenge existing stem and progenitor cell classifications.

Main Methods:

  • Systematic literature review of PubMed.
  • Search terms included 'lung', 'airway', 'alveoli', 'stem cells', 'progenitor', 'repair', and 'regeneration'.
  • Collated research on epithelial stem cell hierarchy and function.

Main Results:

  • Epithelial stem cells are organized hierarchically in the adult lung.
  • These cells are crucial for maintaining lung tissue and regeneration post-injury.
  • New technologies and models blur the lines between stem and progenitor populations.

Conclusions:

  • The understanding of lung stem and progenitor cell populations is rapidly evolving.
  • This knowledge has significant implications for lung disease therapies and regenerative strategies.
  • Further research is needed to fully elucidate the potential of endogenous lung regeneration.