Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Contact-dependent Signaling01:19

Contact-dependent Signaling

46.9K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
46.9K
Contact Angle01:13

Contact Angle

18.5K
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
18.5K
Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

4.6K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
4.6K
Arteries and Arterioles01:16

Arteries and Arterioles

6.5K
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles...
6.5K
Arteries of Lower Limbs01:20

Arteries of Lower Limbs

4.5K
The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular...
4.5K
Functional Groups02:45

Functional Groups

88.2K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
88.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arterial iron regulates vasodilation during anemia via endothelial holo α-globin.

Blood·2026
Same author

Pitfalls of therapies targeting the nitric oxide signaling pathway in heart failure with preserved ejection fraction.

Journal of cardiovascular pharmacology·2026
Same author

Discovery of bioactive constituents from Inula britannica and their anti-pneumonia effects.

Chinese journal of natural medicines·2026
Same author

Transcriptional analyses identify pericyte-centered signaling programs altered by sex and brain region in Alzheimer's Disease.

Communications biology·2026
Same author

Vascular changes and their implications in lipedema.

Frontiers in cell and developmental biology·2026
Same author

Guidelines for evaluating endothelial function in vascular tissue.

American journal of physiology. Heart and circulatory physiology·2026
Same journal

SBK2 Links Cardiac Stress Signaling to Mitochondrial Proteostasis.

Circulation research·2026
Same journal

Myeloid Piezo1 as a Brake on Efferocytosis and Cardiac Repair in the Infarcted Heart.

Circulation research·2026
Same journal

Targeting Late Na<sup>+</sup> Current: Too Late or Better Late Than Never?

Circulation research·2026
Same journal

HFpEF-Any: Human Single-Nuclear Transcriptomics Challenging the Translational Validity of Current HFpEF Models.

Circulation research·2026
Same journal

Myovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

Circulation research·2026
Same journal

Meet the First Authors.

Circulation research·2026
See all related articles

Related Experiment Video

Updated: Jan 27, 2026

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques
09:48

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques

Published on: June 30, 2017

7.8K

Heterocellular Contact Can Dictate Arterial Function.

Xiaohong Shu1,2, Claire A Ruddiman1,3, T C Stevenson Keller1,4

  • 1From the Robert M. Berne Cardiovascular Research Center (X.S., C.A.R., T.C.S.K., A.S.K., Y.Y., M.E.G., A.K.B., B.E.I.), University of Virginia School of Medicine, Charlottesville.

Circulation Research
|March 23, 2019
PubMed
Summary
This summary is machine-generated.

Inducing myoendothelial junctions (MEJs) in conduit arteries shifted their signaling profile to mimic resistance arteries. This change involved reduced nitric oxide and increased endothelial-derived hyperpolarization, influenced by alpha-globin expression.

Keywords:
alpha-globinsbasement membranecarotid arteriesendothelial cellgap junctionsnitric oxideplasminogen activator inhibitor-1

More Related Videos

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

4.6K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K

Related Experiment Videos

Last Updated: Jan 27, 2026

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques
09:48

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques

Published on: June 30, 2017

7.8K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

4.6K
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

3.5K

Area of Science:

  • Vascular Biology
  • Cardiovascular Physiology
  • Cellular Signaling

Background:

  • Resistance and conduit arteries exhibit distinct vasodilatory signaling mechanisms.
  • Resistance arteries utilize myoendothelial junctions (MEJs) for heterocellular communication, unlike conduit arteries.
  • Endothelial-derived hyperpolarization and nitric oxide play differential roles in arterial tone regulation.

Purpose of the Study:

  • To investigate if inducing MEJs in conduit arteries alters their heterocellular signaling.
  • To determine the functional consequences of MEJ formation on vasodilatory capacity.

Main Methods:

  • Plasminogen activator inhibitor-1 (PAI-1) was applied to carotid arteries to induce MEJ formation.
  • Biocytin dye transfer was used to assess endothelial-smooth muscle cell communication.
  • Pressure myography evaluated changes in vasodilatory signaling in response to endothelium-dependent agonists.
  • Alpha-globin expression was analyzed in PAI-1 treated arteries.

Main Results:

  • PAI-1 application significantly increased MEJ-like structures and endothelial-smooth muscle cell dye transfer.
  • PAI-1 treated carotid arteries exhibited a shift from conduit to resistance artery vasodilatory profiles.
  • Nitric oxide signaling was diminished, while endothelial-derived hyperpolarization signaling increased.
  • Alpha-globin expression was upregulated in PAI-1 treated carotid arteries, and its absence prevented nitric oxide inhibition-induced relaxation.

Conclusions:

  • The presence of MEJs is a key factor in modulating heterocellular communication within arteries.
  • Induced MEJs in conduit arteries can alter their vasodilatory signaling by shifting the balance between nitric oxide and endothelial-derived hyperpolarization.
  • Alpha-globin plays a role in the functional changes associated with MEJ formation and altered signaling pathways.