Related Experiment Video

Updated: Jan 27, 2026

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

19.2K

Postsystolic index for distinguishing coronary artery disease in left bundle branch block

Maryam Nabati1, Payam Mahmoudi2, Jamshid Yazdani3

  • 1Department of Cardiology, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Echocardiography (Mount Kisco, N.Y.)
|March 23, 2019
PubMed

Insights

Advanced echocardiographic measures, strain delay index (SDI) and postsystolic index (PSI), may help differentiate coronary artery disease (CAD) in patients with left bundle branch block (LBBB). These markers show promise for identifying CAD in LBBB patients with preserved ejection fraction.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Imaging

Background:

  • Left bundle branch block (LBBB) increases mortality risk, especially from ventricular tachyarrhythmia and myocardial infarction.
  • Differentiating ischemic from nonischemic LBBB is clinically challenging.
  • Advanced echocardiographic parameters are explored for improved diagnostic capabilities in LBBB.

Purpose of the Study:

  • To investigate the utility of strain delay index (SDI) and postsystolic index (PSI) in distinguishing coronary artery disease (CAD) in patients with LBBB.
  • To assess the correlation between echocardiographic findings and the presence of significant CAD.

Main Methods:

  • 102 patients with LBBB underwent comprehensive echocardiography, calculating parameters like LVEF, GLS, SDI, and PSI.
  • Coronary angiography was performed to categorize patients into significant CAD and no significant CAD groups.
  • Statistical analysis compared demographic, clinical, and echocardiographic data between groups.

Main Results:

  • Patients with significant CAD were older and had higher prevalence of traditional CAD risk factors.
  • Significant CAD group showed lower LVEF and GLS.
  • A significant correlation between LVEF and SDI/PSI was observed in the no-CAD group, but not in the significant CAD group.

Conclusions:

  • Strain delay index (SDI) and postsystolic index (PSI) show potential as biomarkers for identifying CAD in LBBB patients.
  • These echocardiographic indices may aid in differentiating CAD in LBBB patients with preserved left ventricular ejection fraction (LVEF).
Abstract

Keywords:
cardiomyopathycomplete left bundle branch blockcoronary artery diseaseechocardiography

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.9K
Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction05:48

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

Published on: August 9, 2022

5.3K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
966
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
414
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
239
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
359
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
623
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
352