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Updated: Jan 27, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

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Cancer Treatment in the Genomic Era

Gary J Doherty1, Michele Petruzzelli1,2, Emma Beddowes1,3

  • 1Department of Oncology, Addenbrooke's Hospital, Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge CB2 0QQ, United Kingdom; email: gd231@cam.ac.uk , Richard.Gilbertson@cruk.cam.ac.uk.

Annual Review of Biochemistry
|March 23, 2019
PubMed

Insights

Genomic data offers insights beyond individual alterations, improving cancer therapy. Integrated approaches and multi-omic data are key to identifying new drug targets and biomarkers for better patient outcomes.

Area of Science:

  • Genomic Medicine
  • Cancer Genomics
  • Translational Oncology

Background:

  • Human cancer's complexity leads to poor clinical outcomes.
  • Targeted cancer drugs improve outcomes for some but not most patients.
  • Genomic alterations drive cancer, but current therapies have limitations.

Purpose of the Study:

  • Review the genomic landscape of cancer.
  • Explore how genomic data can be leveraged for therapeutic insights.
  • Discuss approaches to identify and validate therapeutic genomic targets.

Main Methods:

  • Analysis of genomic and multi-omic cancer data.
  • Review of successes and pitfalls in target validation.
  • Discussion of integrated data approaches for biomarker discovery.

Main Results:

  • Genomic data provides comprehensive insights beyond individual alterations.
  • Multi-omic data enhances understanding of cancer dependencies and drug sensitivity.
  • Integrated data approaches can prioritize cancer vulnerabilities and stratify patients.

Conclusions:

  • Translating genomic data into effective therapies requires integrated approaches.
  • Unbiased genome-wide information can identify novel predictive biomarkers.
  • Future strategies aim to accelerate the clinical application of genomic insights for cancer treatment.
Keywords:
cancer genomicscancer treatmentpersonalized cancer medicineprecision oncologytherapeutic actionability

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