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Genetics of Common, Complex Coronary Artery Disease
Kiran Musunuru1, Sekar Kathiresan2
1Cardiovascular Institute, Division of Cardiovascular Medicine, Department of Medicine, and Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell
|March 23, 2019
Summary
Coronary artery disease (CAD) is a leading global killer with a genetic component. Research faces challenges in gene discovery and clinical translation, but opportunities exist to advance understanding and treatment.
Area of Science:
- Cardiovascular Genetics
- Genomic Medicine
- Public Health
Background:
- Coronary artery disease (CAD) is the primary cause of mortality globally.
- CAD exhibits partial heritability, indicating a significant genetic influence.
- Existing research faces hurdles in identifying causative genes and translating genetic findings.
Purpose of the Study:
- To review the challenges in coronary artery disease gene discovery.
- To explore the difficulties in linking DNA variants to biological function.
- To discuss opportunities for translating genetic research into clinical practice for CAD.
Main Methods:
- Literature review of genetic studies in coronary artery disease.
- Analysis of challenges in gene discovery and functional genomics.
- Discussion of translational research strategies in cardiovascular genetics.
Main Results:
- Gene discovery for complex diseases like CAD remains challenging.
- Connecting DNA variants to functional impact requires advanced methodologies.
- Translating genetic insights into clinical applications for CAD is complex.
Conclusions:
- Despite challenges in gene discovery and functional understanding, advancements in genomic technologies offer new avenues.
- Overcoming barriers in translating genetic findings is crucial for personalized medicine in coronary artery disease.
- Future research should focus on integrated approaches to accelerate clinical application of cardiovascular genetics.
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