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Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
Published on: March 18, 2010
The Missing Diversity in Human Genetic Studies
Giorgio Sirugo1, Scott M Williams2, Sarah A Tishkoff3
1Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract:
The majority of studies of genetic association with disease have been performed in Europeans. This European bias has important implications for risk prediction of diseases across global populations. In this commentary, we justify the need to study more diverse populations using both empirical examples and theoretical reasoning.
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