Saturated Fatty Acids, MUFAs and PUFAs Regulate Ferroptosis
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Updated: Jan 27, 2026

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death
Published on: October 31, 2017
1UND Life Sciences, 2221 NW 5(th) St, Battle Ground, WA 98604, USA; BioScience Research Centre and Department of Medicine, GVP Medical College and Hospital, Visakhapatnam 530048, India.
Abstract:
Apoptosis, necroptosis, autophagy, and ferroptosis are distinct mechanisms of cell death. In this issue of Cell Chemical Biology, Magtanong et al. (2019) demonstrated that exogenous monounsaturated fatty acids (MUFAs) induce a ferroptosis-resistant cell state by suppressing the accumulation of lipid peroxides and decreasing levels of oxidizable polyunsaturated fatty acids (PUFAs).
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