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Treating Surfaces with a Cold Atmospheric Pressure Plasma using the COST-Jet
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Dual RGD-immobilized poly(L-lactic acid) by atmospheric pressure plasma jet for bone tissue engineering.

Fu-Chen Kung1, Yu-Lin Kuo2, Oguzhan Gunduz3

  • 1Department of Health Healing and Health Marketing, Kainan University, Taoyuan 338, Taiwan.

Colloids and Surfaces. B, Biointerfaces
|March 23, 2019
PubMed
Summary

Atmospheric pressure plasma jet (APPJ) surface treatment enhances poly(lactic acid) (PLA) for bone integration. This method improves cell proliferation and differentiation, offering a promising alternative for bone material surface modification.

Keywords:
Atmospheric-pressure plasma jet (APPJ)Bone tissue engineeringOsteoblast-like MG63 cellsPoly(L-lactic acid) (PLA)RGD-peptidesβ-D-Glucan

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Tissue Engineering

Background:

  • Peptide-modified surfaces are crucial for improving implant integration with surrounding bone.
  • Poly(lactic acid) (PLA) is a common biomaterial, but its surface properties can be modified to enhance biological interactions.
  • Atmospheric pressure plasma jet (APPJ) offers a versatile method for surface modification.

Purpose of the Study:

  • To investigate the surface treatment of PLA substrates using APPJ for the polymerization of dual RGD-peptides.
  • To evaluate the effect of APPJ treatment on PLA surface hydrophobicity.
  • To assess the impact of modified PLA surfaces on MG63 cell proliferation, differentiation, and osteocalcin (OCN) expression.

Main Methods:

  • PLA substrates were treated using an atmospheric pressure plasma jet (APPJ) with varying radiofrequency (RF) power.
  • Surface hydrophobicity was quantified by measuring water contact angles.
  • MG63 cell behavior (proliferation and differentiation) was evaluated on treated and untreated PLA.
  • Osteocalcin (OCN) gene expression was analyzed using reverse transcription-polymerase chain reaction (RT-PCR).

Main Results:

  • APPJ treatment led to a tendency for PLA substrates to form a hydrophobic surface.
  • The water contact angle of PLA treated with APPJ was reduced by approximately 54% compared to untreated PLA.
  • APPJ surface treatment significantly increased MG63 cell proliferation and improved material functionality.
  • Enhanced osteocalcin (OCN) expression was observed, indicating improved cellular differentiation.

Conclusions:

  • Pretreatment of PLA with APPJ followed by dual RGD grafting is an effective surface modification strategy.
  • This method significantly enhances cell proliferation and differentiation, crucial for bone material applications.
  • APPJ-based surface modification presents a more appropriate and potentially advantageous alternative to traditional methods for bone implant development.