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Two successful decades of Swiss collaborations to develop new anti-malarials
Rob Hooft van Huijsduijnen1, Timothy Wells2, Marcel Tanner3,4
1Medicines for Malaria Venture, Route de Pré Bois 20, 1215, Geneva, Switzerland.
Malaria Journal
|March 24, 2019
Summary
New malaria drugs offer hope for simpler, effective cures and prophylaxis, combating drug resistance. Switzerland
Area of Science:
- Tropical Medicine
- Infectious Disease Drug Development
- Parasitology
Background:
- A recent surge in new antimalarial drug development addresses global health needs.
- Existing treatments face challenges from emerging drug resistance.
- A highly effective malaria vaccine remains unavailable.
Observation:
- Switzerland has significantly contributed to antimalarial drug innovation.
- Key Swiss institutions include the Swiss Tropical and Public Health Institute, pharmaceutical companies (Novartis, Hoffmann-La Roche), and product-development partnerships like Medicines for Malaria Venture.
- Governmental support from Swiss Agency for Development and Cooperation (SDC) and State Secretariat of Education, Research and Innovation (SERI) has been crucial.
Findings:
- Numerous novel antimalarial drug candidates are progressing through clinical development.
- These new therapies aim for improved efficacy, simpler administration, and resistance circumvention.
- Some candidates show potential for malaria prophylaxis.
Implications:
- Advancements promise more effective malaria cures and prevention strategies.
- International collaboration, particularly Switzerland's role, accelerates progress against neglected tropical diseases.
- Continued investment and research are vital to overcome malaria and drug resistance.
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