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Related Concept Videos

Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

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Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Updated: Jan 27, 2026

Development of an In Vitro Assay to Quantitate Hematopoietic Stem and Progenitor Cells HSPCs in Developing Zebrafish Embryos
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Stem and progenitor cells in skeletal development.

Noriaki Ono1, Deepak H Balani2, Henry M Kronenberg2

  • 1University of Michigan School of Dentistry, Ann Arbor, MI, United States.

Current Topics in Developmental Biology
|March 24, 2019
PubMed
Summary
This summary is machine-generated.

Skeletal stem cells are crucial for bone development, growth, and repair. Recent studies use advanced methods to identify these cells in various bone locations, revealing their collaborative roles.

Keywords:
Bone marrowColony-forming unit fibroblastsGrowth plateIn vivo lineage-tracing experimentsParathyroid hormonePerichondriumPeriosteumSkeletal stem cellsWnt/β-catenin signaling

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Purification of Progenitors from Skeletal Muscle
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Purification of Progenitors from Skeletal Muscle

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Area of Science:

  • Developmental biology
  • Stem cell biology
  • Orthopedics

Background:

  • Stem and progenitor cells are vital for skeletal development.
  • Defining skeletal stem cells has advanced from in vitro to in vivo methods.
  • Understanding these cells is key to bone biology.

Purpose of the Study:

  • To review the evolving definition and identification of skeletal stem cells.
  • To highlight the locations and collaborative functions of these cells.
  • To emphasize the need for further in vivo investigation.

Main Methods:

  • Serial transplantation assays.
  • In vivo lineage-tracing experiments.
  • Sophisticated cellular and molecular approaches.

Main Results:

  • Skeletal stem cells identified in fetal perichondrium, growth plate, bone marrow, and adult periosteum.
  • These cells exhibit diverse characteristics and reside in multiple skeletal sites.
  • Evidence suggests collaborative functions in bone development, growth, maintenance, and repair.

Conclusions:

  • The definition of skeletal stem cells has significantly advanced.
  • Skeletal stem cells are strategically located and functionally collaborative.
  • Further research is needed to fully elucidate in vivo skeletal stem cell behavior and diversity.