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Fibroblast growth factors in skeletal development
David M Ornitz1, Pierre J Marie2
1Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, United States.
Current Topics in Developmental Biology
|March 24, 2019
Summary
Fibroblast growth factors (FGFs) and their receptors (FGFRs) are crucial for bone formation during skeletal development. Mutations in FGF signaling molecules can lead to various skeletal malformations in humans.
Area of Science:
- Developmental Biology
- Genetics
- Orthopedics
Background:
- Fibroblast growth factors (FGFs) and their receptors (FGFRs) play vital roles throughout skeletal development.
- FGF signaling is essential for initiating bone formation in limb buds and cranial mesenchyme.
- FGFs regulate both endochondral and intramembranous ossification processes.
Purpose of the Study:
- To review the functions of the FGF signaling pathway in skeletogenesis.
- To explore skeletal malformations caused by mutations in FGF signaling molecules.
Main Methods:
- Literature review of FGF signaling in skeletal development.
- Analysis of genetic mutations affecting FGF signaling and resulting skeletal phenotypes.
Main Results:
- FGF signaling is critical for mesenchymal condensation and subsequent bone formation.
- Dysregulation of FGF signaling pathways leads to diverse skeletal abnormalities.
- Specific mutations in FGFs and FGFRs are linked to human skeletal disorders.
Conclusions:
- The FGF signaling pathway is a key regulator of skeletal development.
- Understanding FGF signaling is crucial for diagnosing and potentially treating skeletal malformations.
- Further research into FGF signaling mechanisms can elucidate novel therapeutic targets.
Keywords:
ChondrocyteChondrodysplasiaCraniosynostosisEndochondral ossificationFibroblast growth factor receptorsFibroblast growth factorsHeparan sulfate proteoglycansIntracellular signalingIntramembranous ossificationOsteoblastReceptor tyrosine kinaseMore Related Videos
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