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Related Concept Videos

Mismatch Repair01:36

Mismatch Repair

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Overview
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Mismatch Repair01:20

Mismatch Repair

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Overview of DNA Repair02:25

Overview of DNA Repair

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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
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Base Excision Repair01:54

Base Excision Repair

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
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Nucleotide Excision Repair01:08

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Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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Transition from training to practice.

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Safe Placement of Intramedullary Nail and Inter-Physician Variability in Guidewire Placement in Retrograde Tibiotalocalcaneal Fusions.

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Surgical Management Navicular and Cuboid Fractures.

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Evaluating Blood Loss and the Effect of Antiplatelet Treatment in Foot and Ankle Amputations.

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Is Subtalar Joint Cartilage Resection Necessary for Tibiotalocalcaneal Arthrodesis via Intramedullary Nail? A Multicenter Evaluation.

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons·2016
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Advances in forefoot trauma.

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Extensor Tendon Injuries of the Foot and Ankle Caused by Agricultural Trauma: Clinical Characteristics, Complications, and Functional Outcomes.

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Clinical Outcomes of Single-Stage Surgical Intervention for Open Pronation-External Rotation Ankle Fracture-Dislocation.

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Longevity of 2 Piece vs 2+ Piece Stemmed Total Ankle Replacement; Is there an Optimal Length?

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Radiographic improvement of medial column instability after double calcaneal osteotomy without medial column procedures in progressive collapsing foot deformity.

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Clinical study of the superthin anterolateral thigh flap for reconstruction of post-traumatic ankle joint soft-tissue defects.

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Particulated Autologous Cartilage with Platelet-Rich Plasma for Osteochondral Lesions of the Talus in Athletes: Return to Sport and Functional Outcomes at 12 Months.

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The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
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An Innovative Method for Plantar Plate Repair: Technique Guide and Case Report.

J Randolph Clements1, Ajay K Ghai2

  • 1Associate Professor, Carilion Clinic, Virginia Tech School of Medicine / Institute of Orthopaedics and Neurosciences, Roanoke, VA.

The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons
|March 24, 2019
PubMed
Summary
This summary is machine-generated.

Plantar plate disruption causes forefoot pain and joint issues. This study presents a novel surgical technique for plantar plate injury, showing positive 20-month outcomes.

Keywords:
metatarsalgiametatarsophalangeal joint malalignmentplantar platepredislocation syndromesecond metatarsophalangeal joint instability

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Area of Science:

  • Orthopedic Surgery
  • Foot and Ankle Surgery

Background:

  • Plantar plate disruption is a frequent cause of forefoot pain, metatarsalgia, and metatarsophalangeal joint instability.
  • Current surgical repair techniques lack a consensus on clinical superiority.

Observation:

  • A case of plantar plate injury was treated with a novel surgical approach.

Findings:

  • The innovative technique demonstrated positive outcomes over a 20-month follow-up period.
  • This approach offers a potential new solution for plantar plate injuries.

Implications:

  • This case report may influence future treatment strategies for plantar plate injuries.
  • Further research is warranted to validate this new technique in a larger patient cohort.