Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

563
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
563
Structural Protein Function01:56

Structural Protein Function

29.9K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
29.9K
Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

16.8K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
16.8K
Ordinal Level of Measurement00:55

Ordinal Level of Measurement

32.4K
The way a set of data is measured is called its level of measurement. Correct statistical procedures depend on a researcher being familiar with levels of measurement. For analysis, data are classified into four levels of measurement—nominal, ordinal, interval, and ratio.
Data measured using an ordinal scale are similar to nominal scale data, but there is one major difference. The ordinal scale data can be ordered. An example of ordinal scale data is a list of the top five national parks...
32.4K
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.1K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.1K
Peptide Bonds02:43

Peptide Bonds

82.6K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
82.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Load-Dependent Effects of Sodium Glucose Co-Transporter Inhibitors on Work in Human Hypertrophic Cardiomyopathy Living Myocardial Slices.

bioRxiv : the preprint server for biology·2026
Same author

Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer.

Angiogenesis·2026
Same author

Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes.

Cell reports·2026
Same author

Correction to: IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD.

Journal of the American Society of Nephrology : JASN·2026
Same author

STING promotes CD8 T-cell cardiotropism and fibrosis from distinct cellular compartments in doxorubicin cardiomyopathy.

Cardiovascular research·2026
Same author

Patching Up Damaged Hearts.

The New England journal of medicine·2026

Related Experiment Video

Updated: Jan 27, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

14.6K

C-type natriuretic peptide co-ordinates cardiac structure and function.

Amie J Moyes1, Sandy M Chu1, Aisah A Aubdool1

  • 1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

European Heart Journal
|March 24, 2019
PubMed
Summary

C-type natriuretic peptide (CNP) from heart cells preserves cardiac function and structure. Targeting its receptor, NPR-C, may offer new treatments for heart failure and ischemic disorders.

Keywords:
Heart failureCardiomyocyteEndotheliumIschaemia/reperfusion injuryNatriuretic peptideNatriuretic peptide receptor

More Related Videos

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.4K
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

10.1K

Related Experiment Videos

Last Updated: Jan 27, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

14.6K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.4K
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

10.1K

Area of Science:

  • Cardiovascular Biology
  • Endocrinology
  • Molecular Cardiology

Background:

  • C-type natriuretic peptide (CNP) is crucial for vascular homeostasis but its role in cardiac function is unclear.
  • CNP is produced in the heart, suggesting potential intrinsic cardiac functions.

Purpose of the Study:

  • To investigate the specific roles of CNP in maintaining cardiac morphology and contractility.
  • To elucidate the mechanisms by which CNP influences cardiac structure and function.

Main Methods:

  • Utilized cell-specific CNP knockout mouse models (cardiomyocyte, endothelial, fibroblast).
  • Assessed cardiac function and structure in knockout mice under baseline and disease conditions (myocardial infarction, heart failure).
  • Examined natriuretic peptide receptor (NPR)-B and NPR-C knockout mice and human heart failure samples.

Main Results:

  • Endothelial CNP deletion impaired coronary vasoreactivity, similar to NPR-C knockout.
  • Cardiomyocyte CNP deletion worsened infarct size and functional recovery post-ischemia.
  • CNP deficiency in cardiomyocytes, fibroblasts, and NPR-C deficiency exacerbated heart failure phenotypes.
  • Impaired CNP/NPR-C signaling was observed in human heart failure, linked to pro-hypertrophic and pro-fibrotic pathways.

Conclusions:

  • CNP from various cardiac cell types coordinates cardiac structure, function, and vasoreactivity via NPR-C.
  • Targeting NPR-C presents a potential therapeutic strategy for heart failure and ischemic cardiovascular diseases.