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Related Concept Videos

NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

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When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
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Elements have a set number of protons that determines their atomic number (Z). For example, all atoms with eight protons are oxygen; however, the number of neutrons can vary for atoms of the same element. The sum of the number of protons and the number of neutrons is the mass number (A). Atoms with the same atomic number but different mass numbers are called isotopes. Elements can have multiple isotopes, for example, carbon-12, carbon-13, and carbon-14.
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A chemical symbol is an abbreviation used to indicate an element or an atom of an element. For example, the symbol for mercury is Hg. The same symbol is used to indicate one atom of mercury (microscopic domain) or to label a container of many atoms of the element mercury (macroscopic domain).
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Distance Corrections

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To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
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Power Factor Correction

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The power transmission to a factory involves the transfer of apparent power, a combination of active and reactive power. The power factor measures how effectively electrical power is converted into useful work output. The ratio of the real power (KW) that does the work to the apparent power (KVA) supplied to the circuit.
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Isotopes and Radioisotopes01:28

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In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
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IsoCor: isotope correction for high-resolution MS labeling experiments.

Pierre Millard1, Baudoin Delépine1, Matthieu Guionnet1,2

  • 1LISBP, Université de Toulouse, CNRS, INRA, INSA, Toulouse 31077, France.

Bioinformatics (Oxford, England)
|March 24, 2019
PubMed
Summary
This summary is machine-generated.

IsoCor v2 is a new software for correcting raw mass spectrometry data, improving isotopic analysis in systems biology. This tool accurately corrects high-resolution mass spectrometry data for natural isotopes, enhancing metabolic and biochemical studies.

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Area of Science:

  • Biochemistry
  • Systems Biology
  • Bioinformatics

Background:

  • Mass spectrometry (MS) is crucial for isotopic studies in metabolism and biochemical processes.
  • Accurate correction of naturally occurring isotopes in raw MS data is essential for quantitative applications in systems and synthetic biology.
  • Existing high-resolution MS (HRMS) correction methods have limitations in resolving and correcting isotopic species.

Purpose of the Study:

  • To present an updated isotope correction software, IsoCor v2.
  • To introduce a novel correction algorithm for accurate isotopic analysis across various MS resolutions and chemical species.
  • To enhance user accessibility with a graphical user interface (GUI) and a command-line interface (CLI).

Main Methods:

  • Development of a novel correction algorithm for IsoCor v2.
  • Implementation of IsoCor v2 in Python 3.
  • Integration of a user-friendly GUI and a CLI for streamlined use.

Main Results:

  • IsoCor v2 accurately corrects HRMS data by effectively distinguishing resolved isotopic species.
  • The software supports any chemical species and any isotopic tracer at any MS resolution.
  • Enhanced usability through an intuitive GUI and a flexible CLI.

Conclusions:

  • IsoCor v2 offers a significant advancement in correcting HRMS data for isotopic studies.
  • The software improves the accuracy and efficiency of quantitative analyses in systems and synthetic biology.
  • IsoCor v2 is freely available for broad scientific adoption.