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Understanding the Link Between Gut Microbiome and Urinary Stone Disease
Justin A Lee1, Joshua M Stern2
1Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA.
Current Urology Reports
|March 24, 2019
Summary
The gut microbiome (GMB) network, not just specific bacteria, is linked to urinary stone disease (USD). Further research into GMB may offer new prevention strategies for USD.
Area of Science:
- Microbiology
- Urology
- Gastroenterology
Background:
- Recent advances in sequencing technologies have increased research into the gut microbiome (GMB).
- Studies have revealed associations between the GMB and urinary stone disease (USD).
Purpose of the Study:
- To determine if specific gut bacteria or the broader GMB network is responsible for the relationship with USD.
- To review the current evidence linking GMB and USD.
Main Methods:
- Literature review of recent studies on GMB and USD.
- Analysis of the role of specific bacteria versus the overall GMB network.
Main Results:
- Oxalobacter formigenes (OF) was initially considered the primary link due to its oxalate-degrading ability.
- Current evidence suggests the entire GMB network is more likely involved in oxalate absorption and USD risk factors.
- Complex GMB networks are implicated in USD pathophysiology, though causal mechanisms are unclear.
Conclusions:
- The GMB network, rather than isolated bacteria, appears central to USD.
- Further research into GMB may lead to novel prevention strategies for urinary stone disease.
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