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Eosinophilic Gastrointestinal Disorders.

Nirmala Gonsalves1

  • 1Feinberg School of Medicine, Northwestern University, 676 N St. Claire St, Suite 1400, Chicago, IL, 60614, USA. n-gonsalves@northwestern.edu.

Clinical Reviews in Allergy & Immunology
|March 24, 2019
PubMed
Summary
This summary is machine-generated.

Eosinophilic gastrointestinal disorders (EGID) involve eosinophil buildup in the digestive tract, causing various symptoms. Treatment focuses on managing inflammation and identifying food triggers for these immune-mediated conditions.

Keywords:
DysphagiaEosinophilic esophagitisEosinophilic gastritisEosinophilic gastroenteritisFood allergyFood impaction

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Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Background:

  • Eosinophilic gastrointestinal disorders (EGID) are characterized by eosinophilic infiltration in the digestive tract.
  • These conditions include eosinophilic esophagitis (EoE), gastritis, gastroenteritis, enteritis, and colitis.
  • Symptoms vary based on the affected organ and disease extent.

Purpose of the Study:

  • To review the clinical presentation, pathophysiology, and treatment of EGIDs.
  • To highlight the immune-mediated nature and link to food allergens.
  • To discuss current and emerging therapeutic strategies.

Main Methods:

  • Literature review of EGID research.
  • Analysis of clinical symptoms and diagnostic criteria.
  • Summary of treatment modalities, including dietary and medical therapies.

Main Results:

  • EGIDs present with diverse symptoms like dysphagia, abdominal pain, nausea, vomiting, and weight loss.
  • These disorders are immune-mediated, often triggered by food allergens.
  • Effective management involves symptom control, inflammation reduction, and trigger identification.

Conclusions:

  • EGIDs are increasingly recognized chronic inflammatory conditions.
  • Multifaceted treatment approaches are essential for patient management.
  • Further research is needed to fully understand EGID pathophysiology and optimize therapies.