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Updated: Jan 27, 2026
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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
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Assemblies of Peptides in a Complex Environment and their Applications
Huaimin Wang1, Zhaoqianqi Feng1, Bing Xu1
1Department of Chemistry, Brandeis University, 415 South St, Waltham, MA, 02454, USA.
Angewandte Chemie (International Ed. in English)
|March 24, 2019
Summary
Researchers are designing peptide assemblies for complex biological functions. This review covers advances in self-assembly, conformational control, and cellular applications, highlighting future potential.
Area of Science:
- Biochemistry and Materials Science
- Focuses on the intersection of peptide chemistry and biological applications.
Background:
- Peptide assemblies with emergent properties are gaining attention for complex functions.
- Research is expanding to design peptide assemblies for biological systems.
Purpose of the Study:
- To highlight recent developments in peptide assemblies and their biological applications.
- To discuss progress in designing peptides for controlled self-assembly.
- To emphasize spatiotemporal control of peptide assemblies in cellular contexts.
Main Methods:
- Review of recent literature on peptide assembly design and function.
- Discussion of conformational control in peptide self-assembly.
- Exploration of approach-instructed assembly for cellular applications.
Main Results:
- Peptide assemblies offer unique advantages for biological functions.
- Advances in rational design enable conformational control of peptide self-assembly.
- Spatiotemporal control of peptide assemblies is achievable in cellular environments.
Conclusions:
- Peptide assemblies show significant promise for advanced biological functions.
- Challenges remain in harnessing peptide assembly complexity for in vivo applications.
- Future research directions involve further exploration of rational design and cellular integration.
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