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Overexpression of CMTM7 inhibits cell growth and migration in liver cancer

Zi-Ming Huang1,2, Peng-Ling Li3, Peng Yang1

  • 1Department of Emergency Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

The Kaohsiung Journal of Medical Sciences
|March 24, 2019
PubMed

Insights

Chemokine-like factor-like (CMTM) family member 7 (CMTM7) is reduced in liver cancer, inhibiting tumor growth and metastasis. Enforced CMTM7 expression suppresses AKT signaling, leading to cell cycle arrest and acting as a tumor suppressor.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Chemokine-like factor (CKLF)-like, MAL and related proteins for vesicle trafficking and membrane link (MARVEL) transmembrane domain-containing family proteins (CMTMs) are involved in immunity, reproduction, and tumorigenesis.
  • CMTM family member 7 (CMTM7) is expressed in normal tissues but often absent in various cancers.
  • The role of CMTM7 in liver cancer remains largely unexplored.

Purpose of the Study:

  • To investigate the expression of CMTM7 in liver cancer tissues.
  • To determine the correlation between CMTM7 expression and clinical-pathological features of liver cancer.
  • To elucidate the functional role and molecular mechanisms of CMTM7 in liver cancer progression.

Main Methods:

  • Analysis of CMTM7 expression in liver cancer tissues and correlation with TNM staging and metastasis.
  • In vitro studies involving enforced expression of CMTM7 in liver cancer cell lines.
  • Investigation of CMTM7's effects on AKT signaling, cell cycle progression, and expression of related proteins (cyclins, CDKs, p27).

Main Results:

  • CMTM7 expression was significantly reduced in liver cancer tissues.
  • Reduced CMTM7 expression negatively correlated with advanced TNM staging and tumor metastasis.
  • Enforced CMTM7 expression inhibited liver cancer cell growth and migration by suppressing AKT signaling and inducing G0/G1 cell cycle arrest via modulation of cyclin D1, CDK4, CDK6, and p27 levels.

Conclusions:

  • CMTM7 functions as a tumor suppressor in liver cancer.
  • Downregulation of CMTM7 contributes to liver cancer progression by promoting cell cycle progression and metastasis.
  • CMTM7 may represent a potential therapeutic target for liver cancer treatment.
Keywords:
CMTM7cell cyclecell growthliver cancermigration

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