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Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

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In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
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Types of Reports II: Incident or Occurrence Report01:21

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An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
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In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Spongy Bone01:09

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
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Bone Disorders01:29

Bone Disorders

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Bone sarcoma incidence in the Netherlands.

Louren M Goedhart1, Vincent K Y Ho2, P D S Dijkstra3

  • 1Department of Orthopaedic Surgery, University Medical Center Groningen, the Netherlands.

Cancer Epidemiology
|March 24, 2019
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This study analyzed bone sarcoma incidence and survival in the Netherlands from 2000-2014. Treatment at specialized bone tumor centers improved survival for high-grade central osteosarcoma patients.

Keywords:
ChondrosarcomaEwing sarcomaIncidenceOsteosarcomaSarcomaSurvival

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Area of Science:

  • Oncology
  • Epidemiology
  • Orthopedic Surgery

Background:

  • Malignant primary bone tumors, including chondrosarcoma, osteosarcoma, and Ewing sarcoma, necessitate intensive treatment due to aggressive growth and metastatic potential.
  • Understanding the incidence, treatment, and survival patterns of these high-grade bone sarcomas is crucial for effective patient management and public health strategies.

Purpose of the Study:

  • To determine the nationwide incidence, treatment, and survival rates of primary bone sarcomas in the Netherlands over a 15-year period (2000-2014).
  • To evaluate the impact of treatment centralization on clinical outcomes for patients with high-grade central osteosarcoma.

Main Methods:

  • Data were sourced from the Netherlands Cancer Registry, utilizing pathology database notifications.
  • Tumor classification followed ICD-O-3 and WHO 2013 criteria, with incidence calculated per 100,000 person-years (European Standardised Rate).
  • Survival analysis employed Kaplan-Meier curves and Cox proportional hazards regression.

Main Results:

  • Estimated incidence rates per 100,000 ESR: high-grade chondrosarcoma (0.15), high-grade central osteosarcoma (0.25), and Ewing sarcoma (0.15).
  • Five-year overall survival rates: chondrosarcoma (65.9%), osteosarcoma (53.9%), and Ewing sarcoma (59.3%).
  • Treatment at a bone tumor center was associated with improved survival for high-grade central osteosarcoma (HR 0.593).

Conclusions:

  • This study provides comprehensive incidence data for major primary bone sarcomas in a low-migration Northern European population.
  • Centralizing bone sarcoma care demonstrably improves clinical outcomes, particularly for osteosarcoma patients.