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Lung nitroxidative stress in mechanically-ventilated septic patients: A pilot study
J Gorrasi1, G Peluffo2, H Botti2
1Departamento de Emergencia, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Centro de Tratamiento Intensivo, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Center for Free Radical and Biomedical Research (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Journal of Critical Care
|March 24, 2019
Summary
Sepsis and mechanical ventilation increase lung nitroxidative stress. This study found higher nitric oxide (NO) production and related damage markers in septic patients, indicating enhanced lung injury.
Area of Science:
- Critical Care Medicine
- Pulmonary Medicine
- Biochemistry
Background:
- Sepsis and mechanical ventilation are known to induce oxidative stress in lung cells.
- Understanding the role of nitric oxide (NO) and nitroxidative stress is crucial in managing these conditions.
Purpose of the Study:
- To investigate pulmonary nitric oxide (NO) production and nitroxidative stress in mechanically ventilated septic patients.
- To compare these markers between septic and non-septic mechanically ventilated patients and healthy controls.
Main Methods:
- A study involving 69 mechanically ventilated patients (36 with sepsis, 33 without) and 8 healthy controls.
- Analysis of bronchoalveolar lavage fluid (BALF) and plasma for nitrite/nitrate (NOx-), 3-nitrotyrosine, and malondialdehyde (MDA).
Main Results:
- Septic patients exhibited significantly higher levels of BALF NOx-, 3-nitrotyrosine, and MDA compared to non-septic mechanically ventilated patients.
- Both septic and non-septic mechanically ventilated groups showed elevated BALF NOx- compared to healthy controls.
- Higher BALF NOx- levels were observed in non-survivors compared to survivors within the septic group.
Conclusions:
- Early-phase sepsis involves enhanced lung nitroxidative stress.
- Increased NO production leads to NO-derived oxidants, causing protein nitration and lipid peroxidation in the lungs.
- These findings highlight the detrimental role of nitroxidative stress in sepsis-induced lung injury.
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