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Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation

Surgical Tips and Tricks for Performing Porcine Pancreas Transplantation

Published on: July 20, 2022

Don't trick me twice!

Wulf Tonnus¹, Alexia Belavgeni¹, Yanfang Xu²

¹Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.

Kidney International

|March 25, 2019

Summary

This summary is machine-generated.

A first dose of cisplatin chemotherapy makes kidneys vulnerable to a second dose, causing cell death. This unresolved kidney injury may lead to chronic kidney disease.

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Area of Science:

Nephrology
Oncology
Cellular Biology

Background:

Chemotherapy, particularly cisplatin, is a cornerstone of cancer treatment.
Nephrotoxicity is a significant dose-limiting side effect of cisplatin therapy.
The transition from acute kidney injury to chronic kidney disease is not fully understood.

Purpose of the Study:

To elucidate the mechanism of chemotherapy-induced nephrotoxicity.
To investigate how initial cisplatin exposure sensitizes the kidney to subsequent injury.
To explore the role of necroptosis in cisplatin-induced kidney damage and chronic kidney disease development.

Main Methods:

Utilizing a mouse model to study cisplatin-induced nephrotoxicity.
Investigating the cellular and molecular pathways involved in kidney injury.
Analyzing the role of necroptosis in response to sequential cisplatin dosing.

Main Results:

A single dose of cisplatin primes the kidney for enhanced injury upon re-exposure.
This sensitization is mediated by necroptosis, a programmed form of cell death.
Sustained or unresolved kidney injury following cisplatin treatment contributes to the progression to chronic kidney disease.

Conclusions:

Chemotherapy-induced nephrotoxicity involves a mechanism of priming and subsequent necroptosis.
Unresolved acute kidney injury following cisplatin treatment is a critical factor in the development of chronic kidney disease.
Targeting necroptosis pathways may offer a strategy to mitigate long-term kidney damage from chemotherapy.