Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservation of Small Populations02:04

Conservation of Small Populations

16.7K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
16.7K
Genomics02:02

Genomics

40.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.0K
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

100.7K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
100.7K
What is Population Genetics?01:25

What is Population Genetics?

64.6K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.6K
Population Growth00:57

Population Growth

28.2K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.2K
pH Scale02:41

pH Scale

79.2K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
79.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Geographic boundary for the Asian-type DEL in south Asia.

iScience·2026
Same author

Subtle Clinical Clues for Early Diagnosis of Lethal ORAI1 Deficiency in Infants.

Indian journal of pediatrics·2026
Same author

Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny.

Nature methods·2026
Same author

Germline mutational landscape in a large cohort of Indian breast cancer.

BMC cancer·2025
Same author

Identification and Functional Validation of Novel Pathogenic Variants in Primary Immunodeficiencies.

European journal of immunology·2025
Same author

Distribution of HLA class I and II genetic profiles of Indian population: A regional analysis using 30,027 umbilical cord blood samples.

Human immunology·2025

Related Experiment Video

Updated: Jan 27, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.7K

Population-scale genomics-Enabling precision public health.

Ambily Sivadas1, Vinod Scaria1

  • 1GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.

Advances in Genetics
|March 25, 2019
PubMed
Summary

Affordable genomics and precision medicine initiatives are transforming healthcare. Population-scale pharmacogenomics guides optimal therapy selection and minimizes adverse drug events for better public health.

Keywords:
PharmacogenomicsPopulation genomicsPrecision medicineWhole exome sequencingWhole genome sequencing

More Related Videos

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.2K
Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA

Published on: May 9, 2011

10.6K

Related Experiment Videos

Last Updated: Jan 27, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.7K
Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.2K
Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA

Published on: May 9, 2011

10.6K

Area of Science:

  • Genomics and Precision Medicine
  • Pharmacogenomics
  • Public Health

Background:

  • Advancements in affordable genomics technologies are driving global healthcare transformation.
  • Decade-long population sequencing efforts reveal extensive human genetic variation.
  • Genetic variation impacts disease burden and therapeutic response across diverse populations.

Purpose of the Study:

  • To review worldwide population-scale sequencing efforts.
  • To explore the implications for implementing clinical pharmacogenetics.
  • To advance the realization of precision medicine.

Main Methods:

  • Review of global population sequencing initiatives.
  • Analysis of genetic variation data.
  • Assessment of pharmacogenomic data for clinical application.

Main Results:

  • Global sequencing has elucidated vast human genetic diversity.
  • Understanding genetic variation informs differential disease risk and drug response.
  • Population-scale pharmacogenomics offers insights into optimal drug selection and dosing.

Conclusions:

  • Precision medicine implementation is facilitated by population-scale sequencing.
  • Clinical pharmacogenetics can guide national therapeutic policies.
  • Genomic insights are crucial for advancing public health through precision care.