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Nucleic acids

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...

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Allergic Reactions

Allergic Reactions

Biosynthesis of Nucleic Acids

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...

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Related Experiment Video

Updated: Jan 27, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

Nucleic Acid Sensing in Allergic Disorders.

Soroor Farahnak¹, Julia Chronopoulos¹, James G Martin¹

¹Meakins Christie Laboratories, Research Institute of the McGill University Health Centre and McGill University, Montreal, QC, Canada.

International Review of Cell and Molecular Biology

|March 25, 2019

Summary

This summary is machine-generated.

Nucleic acid sensing pathways interact with allergic diseases. Specific sensors can worsen viral infections and asthma, while others may reduce allergic inflammation, offering therapeutic potential.

Keywords:

Adaptive immunity Allergy Asthma Innate immunity Nucleic acid sensing receptors Respiratory viral infection

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Area of Science:

Immunology
Molecular Biology
Allergy Research

Background:

Crosstalk exists between allergic disorders and nucleic acid sensing pathways.
Viral respiratory infections frequently exacerbate asthma, primarily via Toll-like receptor 3 (TLR3).
The allergic state can influence immune responses to viral infections, leading to either exaggerated reactions or protection.

Purpose of the Study:

To review receptors involved in nucleic acid sensing.
To explore the counteracting mechanisms between nucleic acid sensing and allergic responses.
To discuss strategies for intervening in allergic disorders by manipulating nucleic acid sensing.

Main Methods:

Review of current literature on nucleic acid sensing and allergic disorders.
Analysis of the interplay between viral infections, allergic phenotypes, and immune responses.
Examination of experimental strategies in animal and human studies.

Main Results:

Nucleic acid sensing triggers impact allergic phenotypes and antiviral responses based on exposure timing.
TLR3 activation by viruses often leads to asthma exacerbations.
TLR7/8 and TLR9 agonists show potential in inhibiting allergic inflammation.

Conclusions:

Nucleic acid sensing pathways represent a critical interface between allergic diseases and viral immunity.
Therapeutic targeting of nucleic acid sensing machinery holds promise for managing allergic disorders.
Understanding the dual role of these pathways is key for developing novel interventions.