MicroRNA-215: From biology to theranostic applications

Area of Science:

• Molecular Biology
• Genetics
• Oncology

Background:

• MicroRNA-215 (miR-215) is a conserved non-coding RNA with significant roles in human diseases, especially cancer.
• Its involvement spans tumor initiation, progression, and various cellular functions, making it a subject of extensive research.
• High species conservation suggests vital, evolutionarily maintained functions for miR-215.

Purpose of the Study:

• To provide a comprehensive overview of over 150 reports on miR-215.
• To synthesize current knowledge on miR-215's regulation, cellular functions, and roles in disease pathology.
• To explore the potential of miR-215 in developing future theranostic approaches.

Main Methods:

• Literature review and synthesis of over 150 scientific reports.
• Analysis of transcriptional and post-transcriptional regulation mechanisms of miR-215.
• Summary of miR-215's involvement in biological processes and disease pathology.

Main Results:

• miR-215 is implicated in critical biological processes including cell development, survival, cell cycle, proliferation, migration, invasion, and metabolism.
• The microRNA-215 plays diverse roles in the pathology of both nonmalignant and malignant diseases, including various cancers.
• miR-215 is identified as a potential biomarker for diagnosis, prognosis, and prediction, and as a therapeutic target.

Conclusions:

• miR-215 exhibits significant potential as a theranostic molecule for miRNA-based clinical applications.
• Further research and technological advancements are needed to overcome obstacles for translating miR-215 knowledge into clinical practice.
• The continued investigation of miR-215 is expected to yield novel theranostic modalities in the coming years.