Related Experiment Video
Updated: Jan 27, 2026

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
Published on: December 1, 2023
Clinical usefulness of gastric adenocarcinoma predictive long intergenic noncoding RNA in human malignancies: A
Wanwei Liu1, Jiwei Xu1, Caiyun Zhang1
1Department of Hepatobiliary Surgery, Meizhou People's Hospital (Huangtang Hospital), Meizhou, Guangdong Province, PR China.
Background:
Gastric adenocarcinoma predictive long intergenic noncoding RNA (GAPLINC), a newly identified lincRNA, was reported to be aberrantly expressed in several kinds of cancers and played an important role in tumor progression. This study was performed to systematically estimate the prognostic role of GAPLINC expression in cancer patients.
Methods:
Several electronic databases, including PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan Fang databases were searched for potential literature (updated to September 3, 2018). The pooled hazard ratios (HRs), odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with a fixed effects model using Stata12.0 software.
Results:
The pooled results indicated that elevated GAPLINC was significantly related to shorter overall survival (OS) (HR = 1.66, 95%CI: 1.40-1.93, p < 0.001), which was further validated using The Cancer Genome Atlas (TCGA) dataset. Furthermore, high GAPLINC expression was correlated with higher tumor grade (OR = 1.91, 95%CI: 1.35-2.70, p < 0.001), positive lymph node metastasis (OR = 2.80, 95%CI: 1.69-4.64, p < 0.001), deeper infiltration depth (OR = 2.44, 95%CI: 1.43-4.17, p = 0.001) and advanced clinical stage (OR = 3.54, 95%CI: 2.13-5.88, p < 0.001).
Conclusions:
Our results suggest that elevated GAPLINC was associated with poor clinical outcomes and might serve as a promising prognostic biomarker in cancer survivors.
Related Concept Videos
Gastric Motility
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Predicting Molecular Geometry
Directing Effect of Substituents: meta-Directing Groups
Gastric Emptying
Gastric Phase of Digestion
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
Prediction Intervals
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.

