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Longitudinal analysis of sibling correlation on blood pressure using mixed modeling
Qihua Tan1, Hongmei Duan2, Ancong Wang3
1Department of Public Health, Epidemiology and Biostatistics, University of Southern Denmark, Odense, Denmark; Department of Clinical Research, Unit of Human Genetics, University of Southern Denmark, Odense, Denmark.
Annals of Epidemiology
|March 25, 2019
Summary
Genetic factors influence blood pressure levels, with shared family environments playing a role in the longitudinal change of diastolic blood pressure, but not systolic blood pressure.
Area of Science:
- Human Genetics
- Cardiovascular Physiology
- Biostatistics
Background:
- Genetic contributions to blood pressure variation are well-established.
- Investigating genetic control over longitudinal blood pressure changes requires longitudinal study designs, which are less common.
Purpose of the Study:
- To assess genetic and shared environmental effects on blood pressure levels and their longitudinal changes.
- To analyze the rate of change in blood pressure over time using family-based data.
Main Methods:
- Utilized hierarchical modeling of longitudinal family data.
- Employed fractional polynomials for nonlinear age patterns and mixed-effect models for sibling correlations.
- Analyzed blood pressure data from a large-scale family-based longitudinal survey.
Main Results:
- Significant sibling correlations were found for systolic blood pressure levels (0.2) and diastolic blood pressure levels (0.28).
- Significant sibling correlation for the rate of change was observed only for diastolic blood pressure (0.13).
- Female siblings showed higher correlation estimates for longitudinal changes than the overall sample.
Conclusions:
- The rate of blood pressure change is primarily influenced by unique environmental factors.
- Genetic and common family environments may influence the longitudinal change of diastolic blood pressure, but not systolic blood pressure.
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