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Updated: Jan 27, 2026
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
Mortality and morbidity reduction after frequent premature ventricular complexes ablation in patients with left
Antonio Berruezo1, Diego Penela2, Beatriz Jáuregui1
1Heart Institute, Teknon Medical Center, C/Vilana, 12, Barcelona, Spain.
Insights
Ablating frequent premature ventricular complexes (PVCs) significantly improves heart function and reduces cardiac events in patients with left ventricular systolic dysfunction. Sustained PVC reduction lowers the risk of mortality, heart transplant, and heart failure hospitalization.
Area of Science:
- Cardiology
- Electrophysiology
- Heart Failure Research
Background:
- Frequent premature ventricular complexes (PVCs) are associated with left ventricular (LV) systolic dysfunction.
- Ablation of PVCs has shown potential to improve cardiac function in affected patients.
Purpose of the Study:
- To evaluate the long-term hard clinical outcomes following PVC ablation in patients with LV systolic dysfunction.
- To identify prognostic variables associated with improved outcomes after PVC ablation.
Main Methods:
- A prospective multicenter study included 101 patients with LV systolic dysfunction and frequent PVCs undergoing ablation.
- Long-term follow-up (mean 34 months) assessed cardiac mortality, transplantation, and heart failure hospitalizations.
- Statistical analysis identified predictors of hard clinical endpoints.
Main Results:
- PVC ablation was successful in 94% of patients, significantly reducing PVC burden (21% to 3.8%).
- Left ventricular ejection fraction improved (32% to 39%), and NYHA class decreased (2.2 to 1.3).
- Persistent reduction in PVC burden was independently associated with a lower risk of major adverse cardiac events (HR 0.18).
Conclusions:
- Ablation of frequent PVCs leads to sustained functional, structural, and neurohormonal improvements in patients with LV systolic dysfunction.
- Achieving a sustained reduction in PVC burden post-ablation is crucial for reducing long-term cardiac mortality and morbidity.
Aims:
Ablation of frequent premature ventricular complexes (PVCs) improves left ventricular ejection fraction in patients with left ventricular (LV) systolic dysfunction. This study aims to evaluate the long-term hard outcomes and potential prognostic variables in this population.
Methods And Results:
Prospective multicentre study including 101 consecutive patients [56 ± 12 years old, 62 (61%) men] with LV systolic dysfunction and frequent PVCs who underwent PVC ablation before November 2015. The last evaluation performed was considered the long-term follow-up (LTFUP) evaluation. Mean follow-up was 34 ± 16 months (range 24-84 months). Ablation was successful in 95 (94%) patients. There was a significant reduction in the PVC burden from 21 ± 12% at baseline to 3.8 ± 6% at LTFUP, P < 0.001. Left ventricular ejection fraction improved from 32 ± 8% at baseline to 39 ± 12% at LTFUP (P < 0.001) and New York Heart Association class from 2.2 ± 0.6% to 1.3 ± 0.6% (P < 0.001). Brain natriuretic peptide levels decreased from 136 (78-321) to 68 (32-144) pg/mL (P = 0.007). Most of this improvement occurs during the first 6 months after ablation. Persistent abolition of at least 18 points of the baseline PVC burden was independently and inversely associated with the composite endpoint of cardiac mortality, cardiac transplantation, or hospitalization for heart failure during follow-up [hazard ratio 0.18 (0.05-0.66), P = 0.01].
Conclusion:
In patients with LV systolic dysfunction, ablation of frequent PVCs induces a significant improvement in functional, structural, and neurohormonal status, which persists at LTFUP. A sustained reduction in the baseline PVC burden is associated with a lower risk of cardiac mortality, cardiac transplantation, or hospitalization for heart failure during follow-up.
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