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Korean Medication Algorithm for Bipolar Disorder 2018: Comparisons with Other Treatment Guidelines
Jong-Hyun Jeong1, Won-Myong Bahk1, Young Sup Woo1
1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Summary
The Korean Medication Algorithm Project for Bipolar Disorder 2018 (KMAP-BP 2018) aligns with global guidelines for mania treatment but favors combination therapy for psychotic mania and severe depression.
Area of Science:
- Psychiatry and Pharmacology
- Evidence-Based Medicine
Background:
- Bipolar disorder treatment guidelines evolve with accumulating research.
- The Korean Medication Algorithm Project for Bipolar Disorder 2018 (KMAP-BP 2018) provides specific treatment recommendations.
Purpose of the Study:
- To compare the KMAP-BP 2018 treatment recommendations with other recent global bipolar disorder guidelines.
- To identify similarities and differences in treatment strategies across various guidelines.
Main Methods:
- A review of five recently published global treatment guidelines for bipolar disorder.
- Comparative analysis of the KMAP-BP 2018 recommendations against these international guidelines.
Main Results:
- Consensus exists across guidelines for first-line mania treatment using mood stabilizers (MS) or atypical antipsychotics (AAP) monotherapy or combination.
- KMAP-BP 2018 shows a preference for combination therapy in psychotic mania and severe depression, unlike some other guidelines.
- Newer AAPs are consistently recommended as first-line treatments across most guidelines for various bipolar disorder phases.
Conclusions:
- KMAP-BP 2018 largely reflects current global trends and prescription patterns in bipolar disorder management.
- The distinct preference for combination therapy in specific conditions highlights a characteristic of the KMAP-BP 2018.
- Further research is necessary to address identified discrepancies and refine treatment strategies.
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