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Published on: March 12, 2018
Recent progress in LyP-1-based strategies for targeted imaging and therapy
Ningning Song1, Lingzhou Zhao1, Meilin Zhu2
1a Department of Nuclear Medicine , Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , People's Republic of China.
LyP-1 peptide targets p32 protein on tumor and atherosclerotic cells for advanced imaging and drug delivery. This review explores LyP-1 applications in diagnosing and treating various diseases, noting current limitations.
Area of Science:
- Biomedical Engineering
- Molecular Imaging
- Drug Delivery Systems
Background:
- Identifying pathological cell markers aids disease diagnosis and treatment.
- LyP-1 peptide selectively binds to p32 protein, overexpressed in tumor cells and macrophages.
Purpose of the Study:
- To review LyP-1 peptide's properties and applications in disease diagnosis and therapy.
- To highlight LyP-1-based strategies for tumors, metastases, and atherosclerosis.
- To summarize limitations for clinical translation of LyP-1 bioconjugates.
Main Methods:
- Review of existing literature on LyP-1 peptide and its receptor p32.
- Analysis of LyP-1-based imaging probes and drug delivery systems.
- Evaluation of LyP-1 applications in oncology and cardiovascular diseases.
Main Results:
- LyP-1 exhibits homing, internalization, and proapoptotic properties.
- LyP-1-based strategies show promise in diagnosing and treating tumors, metastatic lesions, and atherosclerotic plaques.
- Multiple LyP-1-based diagnostic and therapeutic systems have been developed.
Conclusions:
- LyP-1 peptide is a valuable tool for targeting pathological cells.
- LyP-1-based strategies offer potential for improved disease management.
- Further research is needed to overcome clinical translation challenges for LyP-1 bioconjugates.
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