[Interrelation between the thyroid and calcium-regulating hormones in patients with hypothyroidism]

The paper is concerned with a comparative analysis of the clinical signs of hypothyrosis, thyroid and calcium regulating functions. A decreased or increased reaction of TTH to TRH was revealed; it was accompanied by disorder of calcium regulating function determined by the level of calcitonin, parathyrin and ionized calcium, all these indices being evaluated by a mathematical table proposed by K. I. Myshkin with relation to a severity of the signs of hypothyrosis. An elevated level of calcitonin in the blood was observed in primary hypothyrosis with an increased reaction of TTH to TRH. A percentage ratio of calcitonin to parathyrin grew with an increased level of ionized calcium. Clinical signs of hypothyrosis either decreased or disappeared completely, clinical signs of hypoparathyrosis (relative hypoparathyrosis) appeared making the diagnosis of hypothyrosis difficult. There was a decrease in the calcitonin content in primary hypothyrosis with insufficient reaction of TTH to TRH. A decrease in the percentage ratio of calcitonin to parathyrin was noted in the normal level of ionized calcium. Clinical signs of hypothyrosis in this case were noticeable. In hypophysial hypothyrosis (pangiopopituitarism) there was a decrease in the levels of calcitonin and parathyrin but their percentage ratio remained normal in a decreased level of ionized calcium.