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Regenerative Endodontics: A Systematic Analysis of the Failed Cases
Waleed Almutairi1, Ghaeth H Yassen2, Anita Aminoshariae2
1Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio; Department of Endodontics, College of Dentistry, Qassim University, Qassim, Saudi Arabia.
Journal of Endodontics
|March 26, 2019
Summary
Failed regenerative endodontic treatment (RET) often results from persistent infection, with most cases requiring further intervention. Understanding the causes of RET failure is crucial for improving outcomes in dental trauma and dens evaginatus cases.
Area of Science:
- Endodontics
- Regenerative Dentistry
- Dental Trauma Research
Background:
- Regenerative endodontic treatment (RET) aims to replace damaged pulp tissue.
- Analyzing failed RET cases is essential for refining treatment protocols.
- Understanding failure modes can improve long-term success rates.
Purpose of the Study:
- To systematically review and analyze the causes, diagnosis, and treatment of failed regenerative endodontic treatments.
- To identify common signs of failure and subsequent endodontic interventions in RET cases.
- To provide insights into factors contributing to RET failure.
Main Methods:
- Systematic review of in vivo human studies reporting failed RET cases.
- Searches conducted in PubMed, Web of Science, and ProQuest Dissertations & Theses.
- Definition of failed RET: requiring additional endodontic intervention or extraction post-initial RET.
Main Results:
- 67 failed RET cases from 28 studies were analyzed.
- Dental trauma (59%) and dens evaginatus (30%) were primary etiologies for failure.
- Persistent infection was observed in 79% of failed cases.
- 39% of failures were identified more than 2 years post-treatment.
Conclusions:
- Persistent infection is a primary indicator of RET failure.
- Late detection of failure (over 2 years) is common.
- Detailed reporting of etiology, pre-operative, intra-operative, and post-operative factors is needed for future research on RET failures.
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