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Updated: Jan 27, 2026
07:17
Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
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Reactive oxygen species and cancer: A complex interaction
Sankaralingam Saikolappan1, Binod Kumar2, Gauri Shishodia3
1Department of Biochemistry and Molecular Biology, USA.
Cancer Letters
|March 26, 2019
Summary
Reactive Oxygen Species (ROS) contribute to tumor progression. This review covers ROS sources, roles in the tumor microenvironment, and scavenger systems, focusing on solid tumors.
Area of Science:
- Oncology
- Biochemistry
- Cell Biology
Background:
- Reactive Oxygen Species (ROS) and antioxidant systems play a complex role in cancer.
- Redox homeostasis is crucial for tumor initiation, development, and metastasis.
- The tumor microenvironment influences ROS dynamics during cancer progression.
Purpose of the Study:
- To review the diverse sources of ROS generation within cancer cells.
- To elucidate the multifaceted roles of ROS in the tumor microenvironment.
- To summarize the functions of ROS and their scavenger systems in solid tumor progression.
Main Methods:
- Literature review of existing research on ROS in cancer.
- Synthesis of information on ROS generation, function, and regulation.
- Focus on solid tumors to provide specific insights.
Main Results:
- ROS generation sources in cancer cells are varied and context-dependent.
- ROS significantly impacts tumor progression and metastasis through various mechanisms.
- Antioxidant systems act as crucial scavengers, influencing tumor fate.
Conclusions:
- Understanding ROS dynamics is key to comprehending tumor progression.
- Targeting ROS or antioxidant systems presents potential therapeutic strategies.
- Further research into ROS in the tumor microenvironment is warranted for solid tumors.
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