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Updated: Jan 27, 2026

Harvesting Sperm and Artificial Insemination of Mice
Published on: April 28, 2007
The association between sperm DNA fragmentation and reproductive outcomes following intrauterine insemination, a meta
Qing Chen1, Jin-Yan Zhao1, Xiang Xue1
1Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi province, PR China.
Abstract:
Sperm DNA fragmentation has been suggested as a predictor of pregnancy of intrauterine insemination (IUI), but the controversy still exists. Then a meta-analysis was performed to evaluate the association between sperm DNA fragmentation and reproductive outcomes. A total of 10 articles retrieved from the databases of PUBMED, MEDLINE, EMBASE and WANFANG were included in the meta-analysis. The results indicated that high sperm DNA fragmentation was significantly associated with lower pregnancy rate (RR: 0.34, 95% CI: 0.22-0.52; P < 0.001) and deliveries rate of IUI(RR 0.14, 95% CI:0.04-0.56, P < 0.001). In addition, there was no evidence of publication bias, as suggested by funnel plot, Begg's and Egger's tests. The present meta-analysis indicated that high sperm DNA fragmentation was associated with poor reproductive outcomes of couples undergoing IUI.
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