Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Ecological Succession02:17

Ecological Succession

21.4K
Ecological succession is influenced by the processes of facilitation, inhibition, and toleration. Facilitation occurs when early successional species create more favorable ecological conditions for subsequent species, such as enhanced nutrient, water, or light availability. In contrast, inhibition happens when early successional species create unfavorable ecological conditions for potential successive species, such as limiting resource availability. In some cases, later successional species...
21.4K
Cognitive Dissonance01:38

Cognitive Dissonance

36.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
36.8K
Relative Risk01:12

Relative Risk

2.1K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
Aging01:26

Aging

663
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
663
Transcription Factors02:16

Transcription Factors

82.4K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of microcurrent as an adjunct to donepezil therapy in an Alzheimer's disease mouse model: a pilot study.

Frontiers in aging neuroscience·2025
Same author

Faster Region-Based Convolutional Neural Network in the Classification of Different Parkinsonism Patterns of the Striatum on Maximum Intensity Projection Images of [<sup>18</sup>F]FP-CIT Positron Emission Tomography.

Diagnostics (Basel, Switzerland)·2021
Same author

Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson's Disease.

Neuro-degenerative diseases·2020
Same author

Association of head circumference with cognitive decline and symptoms of depression in elderly: a 3-year prospective study.

Yeungnam University journal of medicine·2019
Same author

Observational Study of Clinical and Functional Progression Based on Initial Brain MRI Characteristics in Patients with Alzheimer's Disease.

Journal of Alzheimer's disease : JAD·2018
Same author

Behavioural and trait changes in parkinsonian patients with impulse control disorder after switching from dopamine agonist to levodopa therapy: results of REIN-PD trial.

Journal of neurology, neurosurgery, and psychiatry·2018

Related Experiment Video

Updated: Jan 27, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.1K

Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging.

Oh Dae Kwon1

  • 1Department of Neurology, School of Medicine, Catholic University of Daegu, Daegu, Korea.

Dementia and Neurocognitive Disorders
|March 26, 2019
PubMed
Summary

The Apolipoprotein E ε4 allele is linked to increased risk of atherosclerosis and Alzheimer's disease. Its presence and gene dose are significant risk factors for late-onset Alzheimer's disease.

Keywords:
Alzheimer's diseaseapolipoprotein Epolymorphism

More Related Videos

Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights
05:26

Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights

Published on: October 25, 2024

1.8K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.7K

Related Experiment Videos

Last Updated: Jan 27, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.1K
Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights
05:26

Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights

Published on: October 25, 2024

1.8K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.7K

Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Background:

  • Apolipoprotein E (ApoE) is crucial for lipid transport in the serum and central nervous system.
  • Three common ApoE alleles (ε2, ε3, ε4) exist, with varying structural stability.
  • The ApoE ε4 allele is implicated in atherosclerosis and amyloid-beta accumulation.

Purpose of the Study:

  • To investigate the role of Apolipoprotein E (ApoE) alleles, particularly ε4, in neurological diseases.
  • To clarify the association between ApoE ε4 and the risk and onset of Alzheimer's disease.

Main Methods:

  • Analysis of existing evidence on Apolipoprotein E allele function.
  • Review of studies examining the correlation between ApoE ε4 and disease pathology.

Main Results:

  • Apolipoprotein E ε4 allele is associated with detrimental effects, including atherosclerosis and brain amyloid-beta buildup.
  • The presence and quantity of the ApoE ε4 allele are identified risk factors for late-onset Alzheimer's disease.
  • Apolipoprotein E ε4 shows a strong link to the early onset of late-onset Alzheimer's disease, though its relationship with early-onset Alzheimer's is weaker.

Conclusions:

  • The Apolipoprotein E ε4 allele plays a significant role in the pathogenesis of Alzheimer's disease, particularly late-onset forms.
  • Understanding ApoE ε4's impact on lipid metabolism and protein aggregation is key to Alzheimer's research.