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Updated: Jan 27, 2026

Research and Development of High-performance Explosives
Published on: February 20, 2016
Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient
Yong Sung Kim1, Seung Jae Kim1, Jongmin Lee1
1Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.
Background:
Cerebellum has an important role in sensorimotor control including speech. Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with Parkinsonism or cerebellar ataxia.
Case Report:
We report a case of MSA-cerebellum subtype associated with emergence of irreversible explosive speech following olanzapine therapy.
Conclusions:
Further investigation into speech problems in MSA according to subtype and disease severity is needed, and side effects of olanzapine therapy should also be considered.
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