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The predictive value of β2-MG and TGF-β for elderly hypertensive nephropathy
Junjie Cao1, Rui Hou1, Jingqian Lu2
1Department of Geriatrics, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China.
Insights
Elevated levels of beta-2 microglobulin (β2-MG) and transforming growth factor-beta (TGF-β) indicate hypertensive nephropathy in elderly patients. Combining these biomarkers improves diagnostic accuracy, reducing missed diagnoses.
Area of Science:
- Nephrology
- Hypertension research
- Biomarker discovery
Background:
- Hypertensive nephropathy is a significant complication of hypertension in the elderly.
- Early and accurate diagnosis is crucial for effective management and preventing kidney damage.
- Novel biomarkers are needed to improve the diagnostic capabilities for hypertensive nephropathy.
Purpose of the Study:
- To investigate the predictive value of beta-2 microglobulin (β2-MG) and transforming growth factor-beta (TGF-β) for hypertensive nephropathy in elderly patients.
- To assess the diagnostic accuracy of individual biomarkers and their combined application using ROC curve analysis.
- To explore the correlation between serum β2-MG and TGF-β levels in patients with hypertensive nephropathy.
Main Methods:
- Retrospective analysis of clinical data from 56 elderly patients with hypertensive nephropathy and 50 age-matched controls with hypertension but no nephropathy.
- Serum levels of β2-MG and TGF-β were quantified using Enzyme-Linked Immunosorbent Assay (ELISA).
- Pearson's correlation was used to analyze the relationship between β2-MG and TGF-β; ROC curve analysis evaluated diagnostic performance.
Main Results:
- Serum levels of both β2-MG and TGF-β were significantly higher in patients with hypertensive nephropathy compared to the control group (P<0.001).
- A significant positive correlation was observed between serum β2-MG and TGF-β levels (r=0.619, P<0.001).
- The area under the curve (AUC) for diagnosing hypertensive nephropathy was 0.786 for β2-MG, 0.793 for TGF-β, and 0.860 for their combined application.
Conclusions:
- Elevated serum β2-MG and TGF-β are strongly associated with hypertensive nephropathy in the elderly.
- The combined detection of β2-MG and TGF-β offers superior diagnostic accuracy compared to individual markers, significantly improving the detection rate.
- These biomarkers show promise as valuable tools for early diagnosis and management of hypertensive nephropathy, potentially reducing missed diagnoses.
Abstract:
Predictive value of β2-microglobulin (β2-MG) and transforming growth factor-β (TGF-β) for elderly hypertensive nephropathy was investigated. The clinical data of 56 patients with hypertensive nephropathy and admitted to Affiliated Hospital of Chengde Medical College from December 2015 to December 2017, were retrospectively analyzed and the clinical data were used as the study group, the clinical data of 50 patients with hypertension, but not nephropathy, were selected as the control group. The expression levels of β2-MG and TGF-β in the serum were detected by ELISA. The correlation between β2-MG and TGF-β was analyzed by Pearson's correlation. The sensitivity and specificity of β2-MG, TGF-β and combined application in the diagnosis of hypertensive nephropathy were analyzed by ROC curve. The expression levels of β2-MG and TGF-β in the serum of the patients in the study group were significantly higher than those in the control group (P<0.001). There was a positive correlation between the expression levels of β2-MG and TGF-β in the serum of the patients in the study group (r=0.619, P<0.001). The AUC of β2-MG in the diagnosis of hypertensive nephropathy was 0.786. The AUC of TGF-β in the diagnosis of hypertensive nephropathy was 0.793. The AUC of the combined application of β2-MG and TGF-β in the diagnosis of hypertensive nephropathy was 0.860. β2-MG and TGF-β were highly expressed in the patients with hypertensive nephropathy, and the expression levels of β2-MG and TGF-β were positively correlated (r=0.619, P<0.001). The combined application of β2-MG and TGF-β in the diagnosis of hypertensive nephropathy could reduce or even avoid the missed diagnosis caused by single detection. The two indicators complemented and confirmed each other, which had a great significance for improving the positive diagnosis rate of hypertensive nephropathy.
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