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Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of

Juthamas Yosudjai1, Sopit Wongkham2, Siwanon Jirawatnotai3

  • 1Department of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.

Biomedical Reports
|March 26, 2019
PubMed

Insights

Aberrant alternative splicing plays a key role in cholangiocarcinoma (biliary cancer) development and progression. Understanding these splicing changes may reveal new therapeutic targets and prognosis markers for this lethal disease.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Cholangiocarcinoma (CCA) is a lethal biliary tract cancer with poorly understood molecular mechanisms.
  • Alternative splicing, a process generating mRNA diversity, is increasingly implicated in cancer.
  • Aberrant splicing is observed in various cancers, including CCA, affecting tumor initiation, maintenance, and metastasis.

Purpose of the Study:

  • To review the aberrant splicing of genes in cholangiocarcinoma.
  • To summarize the functional roles of alternatively spliced genes in CCA carcinogenesis, progression, and aggressiveness.
  • To discuss factors influencing aberrant splicing as potential therapeutic targets or prognostic markers.

Main Methods:

  • Literature review of studies on alternative splicing in cholangiocarcinoma.
  • Analysis of gene splicing patterns and their functional impact.
  • Identification of factors influencing aberrant splicing relevant to CCA.

Main Results:

  • Aberrant alternative splicing contributes significantly to cholangiocarcinoma development and progression.
  • Specific spliced genes and their functions in CCA aggressiveness are identified.
  • Factors influencing aberrant splicing present potential therapeutic and prognostic avenues.

Conclusions:

  • Alternative splicing is a critical factor in cholangiocarcinoma pathogenesis.
  • Targeting aberrant splicing mechanisms offers potential therapeutic strategies for CCA.
  • Splicing alterations may serve as valuable biomarkers for cholangiocarcinoma prognosis.
Keywords:
alternative splicingcholangiocarcinomaspliced gene

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