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Anti-Toxoplasma gondii antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes

Fereshteh Mohamadi1, Mahshid Shakibapour1, Seyedeh Maryam Sharafi2

  • 1Department of Medical Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan 8179498861, Iran.

Biomedical Reports
|March 26, 2019
PubMed

Insights

Toxoplasma gondii (T. gondii) antibodies show selective reactivity with cancer cells, not normal cells. This finding suggests potential for targeted drug delivery in cancer treatment using anti-T. gondii antibodies.

Area of Science:

  • Immunology
  • Parasitology
  • Oncology

Background:

  • Toxoplasma gondii (T. gondii) is a widespread intracellular parasite.
  • T. gondii exhibits inhibitory effects on cancer growth in preclinical models.
  • The role of host immune response in T. gondii's anticancer activity requires further investigation.

Purpose of the Study:

  • To investigate the reactivity of anti-T. gondii antiserum with cancer cell surfaces.
  • To determine if anti-T. gondii antibodies selectively target cancer cells.

Main Methods:

  • Rabbit immunization to generate anti-T. gondii antibodies.
  • Flow cytometry analysis of antiserum reactivity with mouse melanoma and breast cancer cell lines.
  • Comparison of anti-T. gondii antiserum with other anti-parasite antisera.

Main Results:

  • Anti-T. gondii antiserum demonstrated marked reactivity with mouse melanoma and breast cancer cell surfaces.
  • The antiserum showed less reactivity with normal mouse spleen lymphocytes.
  • Other anti-parasite antisera did not exhibit strong selective reactivity with cancer cells.

Conclusions:

  • Anti-T. gondii antiserum selectively reacts with the surface of mouse cancer cells.
  • This selective reactivity suggests potential applications for targeted drug delivery in cancer therapy.
  • Further research into anti-Toxoplasma antibodies could advance cancer treatment strategies.
Keywords:
Toxoplasma gondiiantibodiesbreast cancercell surfacemelanoma

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