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Updated: Jan 27, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Survival and glycemic control in patients with coexisting melanoma and diabetes mellitus
Nina J Karlin1,1, Aaron R Mangold2,2, Shailja B Amin1,1
1Division of Hematology & Medical Oncology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, 85259, AZ, USA.
Aim:
Given the lack of data in the literature, we examined the impact of diabetes mellitus (DM) on melanoma survival and the impact of melanoma on glycemic control.
Materials & Methods:
Patients with melanoma with and without DM were matched 1:1 (2005-2016). Kaplan-Meier analysis was used to estimate overall survival and progression-free survival (PFS). Mixed models compared hemoglobin A1c (HbA1c) and glucose measures over time.
Results:
Mean HbA1c during the year after cancer diagnosis was 6.7%. The 5-year PFS rate was 89% (95% CI: 81-99%) for patients with DM and 63% (95% CI: 51-79%) for patients without DM (p = 0.02).
Conclusion:
Melanoma did not adversely impact glycemic control. The DM did not adversely impact survival of patients with melanoma, although increased PFS for melanoma was seen in individuals with DM.
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