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Published on: August 29, 2013
Failure of immunosurveillance accelerates aging
Maria Perez-Lanzon1,2,3,4,5,6, Laurence Zitvogel6,7,8,9, Guido Kroemer1,2,3,4,5,10,11,12
1Equipe 11 labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.
Abstract:
Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs, thereby speeding up the aging process. These results suggest that immunosurveillance plays a much broader role in maintaining organismal health than it had been suspected.
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