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Updated: Jan 27, 2026

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
Published on: January 30, 2020
Beyond Advanced Cardiac Life Support: Dual-sequential Defibrillation for Refractory Ventricular Fibrillation after
Kenneth L Frye1, Ademola Adewale2, Elijah Kennedy1
1Emergency Medicine, Florida Hospital, Orlando, USA.
Refractory ventricular fibrillation, a rare cardiac arrest complication, was successfully treated with dual-sequential defibrillation (DSD) when standard Advanced Cardiac Life Support (ACLS) failed. DSD offers a potential alternative for patients unresponsive to conventional treatments.
Area of Science:
- Cardiology
- Emergency Medicine
- Critical Care Medicine
Background:
- Refractory ventricular fibrillation presents a significant challenge in cardiac arrest management.
- Current Advanced Cardiac Life Support (ACLS) protocols lack specific recommendations for refractory cases.
- Standard defibrillation techniques are not always effective in restoring normal sinus rhythm.
Observation:
- A 56-year-old male experienced in-hospital cardiac arrest with refractory ventricular fibrillation.
- Multiple attempts using standard defibrillation were unsuccessful in converting the arrhythmia.
- Dual-sequential defibrillation (DSD) was employed as a rescue strategy.
Findings:
- Dual-sequential defibrillation (DSD) successfully converted the refractory ventricular fibrillation to normal sinus rhythm.
- This case demonstrates the efficacy of DSD in a scenario where standard ACLS failed.
- The patient achieved return of spontaneous circulation after DSD intervention.
Implications:
- Dual-sequential defibrillation (DSD) may represent a viable and effective treatment option for refractory ventricular fibrillation.
- This approach could improve outcomes for patients with challenging cardiac arrest presentations.
- Further research into DSD protocols for refractory ventricular fibrillation is warranted to establish its role in advanced cardiac life support.
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