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Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia - A case series

Tirza Wouters1, Natasja Hendriks2, Margot Koeneman2

  • 1Department of Obstetrics and Gynaecology, Catharina Hospital, Eindhoven, the Netherlands.

Case Reports in Women'S Health
|March 26, 2019
PubMed

Treatment for cervical intraepithelial neoplasia (CIN) often consists of an excisional procedure. However, less invasive treatment methods have been explored, such as topical treatment with imiquimod cream. Imiquimod has been proven to be effective in the regression of vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN). Previous studies have investigated the effect of imiquimod in CIN and showed well tolerated adverse effects. During a current study in the Netherlands, a number of adverse events have occurred. This case series presents a selection of these. Gynaecologists should be aware of the possible adverse effects of topical treatment with imiquimod cream.

Keywords:
AldaraCINHSILImiquimodNauseaSide effects

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