Related Experiment Video
Updated: Jan 27, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
New Platinum(IV) and Palladium(II) Transition Metal Complexes of s-Triazine Derivative: Synthesis, Spectral, and
Fatima A I Al-Khodir1, Hana M A Abumelha1, Tarfah Al-Warhi1
1Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Saudi Arabia.
Abstract:
New Pd(II) and Pt(IV) triazine complexes [Pt3(L )2(Cl)9(H2O)3].3Cl.3H2O (1), [Pt3(L )2(Cl)9(H2O)3].3Cl (2), [Pt3(L )2(Cl)9(H2O)3].3Cl (3), [Pt2(L )2(Cl)6(H2O)2] .2Cl.4H2O (4), [Pd3(L )2(H2O)6] .3Cl2 (5), [Pd3(L )2(H2O)6].3Cl2 (6), [Pd3(L )2(H2O)6].3Cl2 (7), and [Pd2(L )2(H2O)4].2Cl2 (8) were synthesized and well characterized using elemental analyses, molar conductance, IR, UV-Vis, magnetic susceptibility, 1H, 13C-NMR spectra, and thermal analyses. These analyses deduced that the L , L , and L ligands act as tridentate forming octahedral geometry with Pt(IV) metal ions and square planar geometry in case of Pd(II) complexes but the L ligand acts as bidentate chelate. The molar conductance values refer to the fact that all the prepared s-triazine complexes have electrolyte properties which are investigated in DMSO solvent. Surface morphology behaviors of prepared complexes have been scanned using TEM. The crystalline behavior of triazine complexes has been checked based on X-ray powder diffraction patterns. The antimicrobial activity of the free ligands and their platinum(IV) and palladium(II) complexes against the species Staphylococcus aureus (G+), Escherichia coli (G-), Aspergillus flavus, and Candida albicans has been carried out and compared with the standard one. The coordination of ligands towards metal ions makes them stronger bacteriostatic agents, thus inhibiting the growth of bacteria and fungi more than the free ligands. The cytotoxic assessment IC50 of the free ligands and its platinum(IV) complexes in vitro against human colon and lung cancer cell lines introduced a promising efficiency.
Related Concept Videos
Properties of Transition Metals
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Phase Transitions
Crystal Field Theory - Octahedral Complexes
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
Electron Transport Chain: Complex III and IV
Formation of Complex Ions

